Hotair overexpression
WebMay 21, 2012 · HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast, colon and liver ... WebOverexpression of HOTAIR is associated with metastasis in multiple cancers, including breast, pancreatic, lung, hepatocellular carcinoma, and colorectal [19,154–157]. HOTAIR …
Hotair overexpression
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WebHOTAIR was the first lncRNA to be identified for its role in metastasis. Overexpression of HOTAIR is associated with metastasis in multiple cancers, including breast, pancreatic, … WebJun 1, 2024 · Results. A negative correlation between adipose tissue HOTAIR expression (arm or abdominal subcutaneous fat depots) and regional adiposity under the status of severe obesity or uraemia was observed.HOTAIR overexpression using human immortalized abdominal preadipocytes further revealed its anti-adipogenic effects. Integrative analysis …
WebApr 3, 2024 · The transport of multivesicular bodies (MVBs) after overexpression of HOTAIR was detected by transmission electron microscopy and confocal microscopy analysis of cluster determinant 63 (CD63) with synaptosome associated protein 23 (SNAP23). The mechanism of HOTAIR’s regulation of Ras-related protein Rab-35 (RAB35), vesicle … WebOct 24, 2024 · HOTAIR overexpression promoted tumor growth in mice bearing HeLa and exposed to radiation. Radiotherapy might inhibit cervical cancer cell growth through HOTAIR/HIF-1α pathway. HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in …
WebNon-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs transcribed from the genome, which modulate … WebOct 1, 2024 · Based on the overexpression of HOTAIR in a variety of human cancers, technologies related to its utility as a useful target for early cancer detection and treatment are rapidly developing, such as the liposome-encapsulated antisense oligonucleotide probe 99 m Tc-HYNIC-ASON targeting HOTAIR for its in vivo imaging in malignant GBM …
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WebAlso, overexpression of HOTAIR promoted the migration and invasion ability of lung cancer cells, confirmed by wound healing assay and transwell assay, which was suppressed by overexpression of miR-149-5p. Furthermore, dual-luciferase reporter assay indicated that miR-149-5p could bind both HOTAIR and the 3’UTR of HNRNPA1. fa-forg-tech hungária kftWebDec 6, 2024 · HOTAIR overexpression enhanced, whereas its knockdown reduced, cell proliferation, cachexia-associated pro-inflammatory cytokine expression, and muscle atrophy. Cachexia-associated symptoms were ameliorated in mice bearing Hotair-knockdown bladder tumors undergoing cisplatin treatment. We demonstrate for the first … fa for allWebFeb 7, 2024 · Downregulation of HOTAIR was detected in osteosarcoma, which predicted poor prognosis of patients with osteosarcoma. Moreover, cell migration, invasion, and proliferation were suppressed by HOTAIR overexpression in osteosarcoma. Furthermore, LPR5 was a direct target of HOTAIR, which was upregulated in osteosarcoma. dog friendly coach tripsWebApr 4, 2024 · Moreover, the overexpression of hsa-miR-30a-5p inhibited the expression of GRP78 and PD-L1, but Hotair overexpression in LSCC cells rescues both proteins. Furthermore, the impacts of hsa-miR-30a-5p upregulation on the apoptosis and proliferation of LSCC cells were rescued by overexpression of Hotair. Finally, we combined si-Hotair … dog friendly christmas tree decorationsWebDec 29, 2024 · A valuable new mouse model was developed for studying the functional effects of overexpressing HOTAIR and the mechanism of action of HOTAIR, and used to demonstrate overexpression of HOTAIR promoted breast cancer metastasis to the lung. Mechanistically, HOTAIR overexpression changed the chromatin from a closed, inactive … dog friendly coastal cottages scotlandWebApr 12, 2024 · Carolina BalloonFest is the second-oldest hot air balloon festival in the world and been running for nearly 50 years. The Statesville -based festival brings in close to … faforlife.com loginWebMay 5, 2024 · HOTAIR regulates genes related to key depot-specific pathways in hASCs. HOTAIR is one of the most differentially expressed transcripts between GF and ABD hASCs (Divoux et al. 2024), and its role in adipogenesis was suggested by our previous overexpression study (Divoux et al. 2014).Additionally, prior studies in several cancer … faformec congres